Home Home McDonald's - South Gloster Street Share 519 South Gloster Street Tupelo, MS 38801 (662) 844-5505 Hours: Monday - Tuesday 6:00 a.m. - 1:00 a.m., Wednesday 6:00 a.m. - 12:00 a.m., Thursday - Saturday 24 HOURS, Sunday 6:00 a.m. - 1:00 a.m. Website Save McDonald's - South Gloster Street519 South Gloster Street Tupelo, MS 38801DetailsOpen in Google Maps Map Overview hamburgers, low-fat ice cream Cuisines Fast Food